本公司经销CD33/Siglec-3，CD33抗体，克隆类型为polyclonal，宿主来源是Rabbit，CD33/Siglec-3CD33抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1514R
英文名称：Anti-CD33/Siglec-3
中文名称：CD33抗体
其他名称：CD 33; CD33 antigen; CD33 molecule; FLJ00391; gp67 ; Myeloid cell surface antigen CD33; Myeloid cell surface antigen CD33 precursor; p67 ; Sialic acid binding Ig like lectin 3; Sialic acid binding immunoglobulin like lectin 3; SIGLEC3.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 40/37kDa
纯化方法：affinity purified by Protein A
交叉反应：rat, mo
产品介绍：CD33 is found on granulocyte ａnd macrophage precursors in the bone marrow, but is not on pluripotent stem cells. The protein is also expressed on, ａnd is a useful marker for, peripheral monocytes. It is also useful for distinguishing myelogenous leukaemia cells from lymphoid or erythroid leukaemias.Function : Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase（s） via their SH2 domain（s） that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia （in vitro）.Subunit : Interacts with PTPN6/SHP-1 ａnd PTPN11/SHP-2 upon phosphorylation.Subcellular Location : Cell membrane; Single-pass type I membrane protein.Tissue Specificity : Monocytic/myeloid lineage cells.Post-translational modifications : Phosphorylation of Tyr-340 is involved in binding to PTPN6 ａnd PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.Similarity : Belongs to the immunoglobulin superfamily. SIGLEC （sialic acid binding Ig-like lectin） family. Contains 1 Ig-like C2-type （immunoglobulin-like） domain. Contains 1 Ig-like V-type （immunoglobulin-like） domain.CD33（Siglec-3）也是急性淋巴细胞白血病抗原,细胞表面跨膜糖蛋白.CD33表达于早期B淋巴细胞,某些粒性白细胞,骨髓基质细胞,部分上皮组织及其起源的肿瘤细胞中也有表达.主要应用于某些恶性淋巴瘤和白血病的分型.