文章关键词：(4E)-反式环辛烯-活性酯，(4E)-TCO-NHS ester，1191901-33-3

一、基本信息

【性质简介】：(4E) - TCO-NHS ester is a compound with unique properties, which can exist in solid or viscous liquid forms, mainly depending on the molecular weight of the PEG (polyethylene glycol) it binds to. In most cases, it presents a pure white solid form, giving people a fresh ａnd delicate feeling. In the field of chemistry, the TCO component of (4E) - TCO-NHS ester exhibits impressive site-specific binding ability, which is achieved through click chemistry. This click chemistry method enables precise binding of (4E) - TCO-NHS ester with biomolecules such as antibodies, proteins, or probes, providing great convenience for biomedical research.

It is worth mentioning that the TCO part of the (4E) - TCO-NHS ester can react with tetrazine through a mechanism called anti electron demand Diels Alder cycloaddition reaction. This reaction process is not only efficient, but also capable of forming stable dihydropyridazine bonds, ensuring a stable connection between the (4E) - TCO-NHS ester ａnd the target molecule. The formation of this stable dihydropyridazine bond provides a powerful tool for labeling, tracing, ａnd detection in biomedical research. Whether in drug development, biological imaging, or protein interaction research, (4E) - TCO-NHS ester has demonstrated its unique value ａnd broad application prospects.

【中文名】：(4E)-反式环辛烯-活性酯

【英文名】：(4E)-TCO-NHS ester

【CAS号】：1191901-33-3

【化学式】：C13H17NO5

【分子量】：267.28

【结构式】：

二、详情介绍

【外观】：固体/粉末

【溶解性】：溶于大部分有机溶剂

【规格】：1g，5g，10g

【纯度】：95%+

【储存条件】：本品应密封避光，储存于阴凉、干燥、通风处，避免反复冻融，储液应该立即使用

【注意事项】：陕西新研博美生物科技有限公司提示，试剂仅用于科学研究或者工业应用等非医疗目的，非药用，非食用！

三、相关试剂

(2E)-TCO-PNB ester

(4E)-TCO-PNB ester

(4E)-TCO-CycP-O-PNB ester

(4E)-TCO-amine

(4E)-TCO-PEG4-amine

TCO-PEG5-amine

TCO-amine hydrochloride

(4E)-TCO-C3-PEG3-C3-amine

(4E)-TCO-N(PEG3-amine)2

(4E)-TCO-PEG3-Maleimide

TCO-Mal

(4E)-TCO-OH

(4E)-TCO-CycP-OH

(4E)-TCO-CycP-PEG2-OH

BDP FL-PEG4-(4E)-TCO

TCO-PEG3-Cyanine5

TCO-PEG3-FITC

Sulfo-Cy5-(4E)-TCO

本文整理分享来自于小编zmy

原创作者：陕西新研博美生物科技有限公司