GRP78 BiP [2-7] Catalog Number：OM638616
发布时间：2024/8/30 14:13:11关注度：2756
Product Profile
| Product Name | GRP78 BiP [2-7] |
| Antibody Type | Primary Antibodies |
| Product description | Binding immunoglobulin protein (BiP) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) is a protein that in humans is encoded by the HSPA5 gene. BiP is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum (ER) that binds newly synthesized proteins as they are translocated into the ER, ａnd maintains them in a state competent for subsequent folding ａnd oligomerization. BiP is also an essential component of the translocation machinery, as well as playing a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. Like many stress ａnd heat shock proteins, BiP/GRP78 has potent immunological activity when released from the internal environment of the cell into the extracelluar space.specifically, it feeds anti-inflammatory ａnd pro-resolutory signals into immune networks, thus helping to resolve inflammation. More
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| Immunogen | peptide |
Key Feature
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBICCIHC |
| | WB:1:5,000-1:10,000
ICC:1:200 |
| Species Reactivity | Human |
| Concentration | 2 mg/mL. |
Target Information
| Alternative Names | 78 kDa glucose regulated protein antibody
78 kDa glucose-regulated protein antibody
AL022860 antibody
AU019543 antibody
BIP antibody
D2Wsu141e antibody
D2Wsu17e antibody
Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 antibody
Endoplasmic reticulum lumenal Ca2+ binding protein grp78 antibody
Epididymis secretory sperm binding protein Li 89n antibody
FLJ26106 antibody
Glucose Regulated Protein 78kDa antibody
GRP 78 antibody
GRP-78 antibody
GRP78 antibody
GRP78_HUMAN antibody
Heat shock 70 kDa protein 5 antibody
Heat Shock 70kDa Protein 5 antibody
Heat shock protein family A (Hsp70) member 5 antibody
HEL S 89n antibody
Hsce70 antibody
HSPA 5 antibody
HSPA5 antibody
Immunoglobulin Heavy Chain Binding Protein antibody
Immunoglobulin heavy chain-binding protein antibody
mBiP antibody
MIF2 antibody
Sez7 antibody More |
| Molecular Weight(MW) | 78kDa |
| Cellular Localization | Cylasm, endoplasmic reticulum lumen |
Database Links
Application
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Application
Fig1: Western blot analysis on human spermatozoa lysates using anti- GRP78 mouse mAb.
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Application
Fig2: ICC staining GRP78 in Hela cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
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Application
Fig3: Western blot analysis of GRP78 on hybrid fish (crucian-carp) heart tissue lysate using anti-GRP78 antibody at 1/500 dilution.
| Positive Control | Hela, human spermatozoa |
| Application Notes | WB:1:5,000-1:10,000
ICC:1:200 |
Additional Information
| Form | Liquid |
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
原创作者：上海笃玛生物科技有限公司
第12年
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