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Peprotech 200-04 Recombinant Human IL-4
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相关标签：Recombinant,Human,IL-4,重组,人IL-4,Peprotech,200-04
详细内容
Peprotech 200-04 Recombinant Human IL-4
Recombinant Human IL-4
Catalog Number:
200-04
Synonyms:
BCGF, BCDF, B cell stimulating factor （BSF-1）
Description:
IL-4 is a pleiotropic cytokine that regulates diverse T ａnd B cell responses including cell proliferation, survival ａnd gene expression. Produced by mast cells, T cells ａnd bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, ａnd IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 ａnd IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production ａnd allergy. Recombinant human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.
AA Sequence:
MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
Biological Activity:
The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106units/mg.
Cross Reactivity:
Human, Bacteria, Rat, Mouse, Leech
Research Interests:
 | Apoptosis |  | Cancer |
 | Cell Culture |  | Immune System |
 | Inflammation |  | Proliferation |
 | Stem Cells & Differentiation |  | Allergy |
 | Transplantation | ||
Country of Origin:
USA
Recombinant,Human,IL-4,重组,人IL-4,Peprotech,200-04
