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美国Peprotech细胞因子,Recombinant Human IGF-1
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相关标签：北京现货,Recombinant,Human,IGF-1,金牌供应,Peprotech,100-11,重组人IGF-1
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美国Peprotech细胞因子,Recombinant Human IGF-1
Recombinant Human IGF-I
Catalog Number:
100-11
Synonyms:
Insulin-like Growth Factor-I, Somatamedin C, IGF-IA
Description:
The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation ａnd survival of various cell types including muscle, bone, ａnd cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin ａnd relaxin. The IGFs are similar by structure ａnd function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I ａnd IGF-II signal through the tyrosine kinase type I receptor （IGF-IR）, but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal ａnd C-terminal propeptide regions. Recombinant human IGF-I ａnd IGF-II are globular proteins containing 70 ａnd 67 amino acids, respectively, ａnd 3 intra-molecular disulfide bonds.
AA Sequence:
GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
Biological Activity:
The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105units/mg.
Cross Reactivity:
Bacteria, Chicken, Cow, Frog, Horse, Monkey, Mouse, Pig, Rat, Sheep, Tiger Salamander, Hamster, Human, N/A
Research Interests:
 | Angiogenesis/ Cardiovascular |  | Bone, Skeletal, Cartilage |
 | Diabetes / Weight Regulation |  | Inflammation |
 | Proliferation |  | Wound Healing |
Country of Origin:
USA
北京现货,Recombinant,Human,IGF-1,金牌供应,Peprotech,100-11,重组人IGF-1
