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CD3抗体(17A2):SC-18843

CD3抗体(17A2):SC-18843

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更新日期:2026/8/24 23:48:41

生 产 地:美洲

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简单介绍:CD3抗体(17A2):SC-18843
CD3 Antibody (17A2) is a rat monoclonal IgG2b provided at 200 μg/ml
raised against γδ TCR-positive T-T hybridoma D1 cells of mouse origin
recommended for detection of CD3 of mouse origin by IF, IP and FCM
fluorescein conjugate for FCM, sc-18843 FITC, 100 tests
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相关标签:CD3抗体(17A2):SC-18843

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CD3抗体(17A2):SC-18843

Ordering Information
Product Name Catalog # Unit Price Qty Add
CD3 Antibody (17A2) sc-18843 200 µg/ml $279
CD3 Antibody (17A2) FITC sc-18843 FITC 100 tests in 2 ml $292
siRNA Gene Silencers (click product name for more information)
Product Name Catalog # Unit Price Qty Add
CD3 siRNA (m) sc-29988 10 µM $258
CD3 (m)-PR sc-29988-PR 10 µM, 20 µl $23
shRNA Plasmids (click product name for more information)
Product Name Catalog # Unit Price Qty Add
CD3 shRNA Plasmid (m) sc-29988-SH 20 µg $520
shRNA Lentiviral Particles (click product name for more information)
Product Name Catalog # Unit Price Qty Add
CD3 shRNA (m) Lentiviral Particles sc-29988-V 200 µl $625

The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of gamma and epsilon chains (©é), a heterodimer of delta and epsilon chains (∂é) and a homodimer of two zeta chains (ΩΩ) or a heterodimer of zeta and eta chains (Ωh). The Ω and h chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The ©, é and ∂ chains each contain a single copy of a conserved immunoreceptor tyrosine-based activation motif (ITAM). In contrast, the Ω chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP⁻⁷0 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP⁻⁷0 SH2 domains bound to the Ω chain ITAMs has been solved.

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CD3抗体(17A2):SC-18843

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