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人牙龈成纤维细胞

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价格：￥电议

更新日期：2026/8/24 23:48:28

生产地：美洲

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简单介绍：人牙龈成纤维细胞
成纤维细胞是间叶细胞，它在成熟的生物体发育过程中具有许多重要的功能。成纤维细胞与结缔组织中细胞外基质的合成有关，并且在创伤愈合过程中起着重要作用。许多疾病都与成纤维细胞有关，不仅因为成纤维细胞与病原论有关，而且纤维症伴随着组织中其它细胞类型的损害。成纤维细胞是最易获得的哺乳动物细胞类型而且最适于体外培养。牙龈成纤维细胞是牙龈组织中的主要成分，并在维持牙龈健康中起着关键作用。人牙龈纤维原细胞表达广泛的表面分子，主要包括CD9, CD26, CD55, CD59, CD63, CD71, CD86 CD95, CD99和CD117。也有证据表明牙龈成纤维细胞为蛋白酶激活受体1和

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推荐培养基:（FM, Cat. No.2301）

产地：San Diego,US
品牌：ScienCell

储存：液氮

运输：干冰

用途：科研

Fibroblasts are mesenchymal cells with many vital functions during development ａnd in adult organisms. They are responsible for much of the synthesis of extracellular matrix in connective tissues ａnd play major roles in wound healing. Many diseases are associated with fibroblasts, either because fibroblasts are implicated in their etiology or because of the fibrosis that accompanies damage to other cell types in tissues. Fibroblasts are among the most accessible normal mammalian cell types ａnd still the most amenable to culture in vitro. Gingival fibroblasts are the major constituents of gingival tissue ａnd play a key role in their health maintenance [1]. Human gingival fibroblasts （HGF） express a wide surface molecular panel including mainly CD9, CD26, CD55, CD59, CD63, CD71, CD86 CD95, CD99 ａnd CD117 [2]. They were also demonstrated to express mRNAs for protease-activated receptor-1 （PAR-1）ａnd PAR-3 [3].

HGF from ScienCell Research Laboratories are isolated from human gingiva. HGF are cryopreserved at passage one ａnd delivered frozen. Each vial contains >5 x 10⁵ cells in 1 ml volume. HGF are characterized by their spindle morphology ａnd immunofluorescent method with antibody to fibronectin. HGF are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi. HGF are guaranteed to further expand for 15 population doublings at the conditions provided by ScienCell Research Laboratories.

Reference
[1] Poggi, P., Rodriguez y Baena, R., Rizzo, S., Rota, M. T. （2004） Mouthrinses with alcohol: cytotoxic effects on human gingival fibroblasts in vitro. J Periodontol. 74（5）:623-9.
[2] Di Domenico, G., Del Vecchio, L., Postiglione, L., Ramaglia, L. （2004） Immunophenotypic analysis of human gingival fibroblasts ａnd its regulation by Granulocyte-Macrophage Colony-Stimulating Factor （GM-CSF）. Minerva Stomatol. 52（3）:81⁻⁷, 87-91.
[3] Tanaka, N., Morita, T., Nezu, A., Tanimura, A., Mizoguchi, I., Tojyo, Y. （2004） Thrombin-induced Ca2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 （PAR-1）. Life Sci. 73（3）:301-10.