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人滑膜细胞

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价格：￥电议

更新日期：2026/8/24 23:48:28

生产地：美洲

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简单介绍：人滑膜细胞
人滑膜细胞呈成纤维细胞状，是健康的滑膜组织中主要的细胞类型。滑膜细胞形成被称为滑膜衬里层的特殊结构。电子显微镜下可观察到内层中细胞与细胞间广泛地接触。滑膜细胞产生润滑液成分，并且与关节腔的吸收和血液/润滑液交换有关。滑膜细胞增生，表现为不依赖于支持物生长，并且分泌大量的效应分子来促进炎症和关节损坏，同时，它们自身也是自分泌和旁分泌网络中效应因子的一部分。滑膜细胞表达钙粘蛋白-11，这为研究滑膜组织的组成和形态提供了新的线索，同时也是重要的治疗目标。

人滑膜细胞提取于人滑膜组织，原代冻存。每管含有细胞数>5×105 cells/ml，此细胞通过CD90和Fibrone

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详细内容

推荐培养基:（SM, Cat. No. 4701）

产地：San Diego,US
品牌：ScienCell

储存：液氮

运输：干冰

用途：科研

Human synoviocytes （HS）, the predominant cell type of healthy synovial tissue, are fibroblast-like cells. The Synoviocytes form a distinct structure called the synovial lining layer. Electron microscopy revealed extensive cell-to-cell contacts within the lining layer [1]. The Synoviocytes produce synovial fluid components ａnd are responsible for absorption from the joint cavity, ａnd for blood/synovial fluid exchanges. The synoviocytes proliferate, show anchorage-independent growth, ａnd also secrete a variety of effector molecules that promote inflammation ａnd joint destruction and, themselves are part of a complex network of autocrine ａnd paracrine acting factors. The synoviocytes express cadherin-11 providing new insight into synovial tissue organization ａnd morphogenesis [2] ａnd of interest as a therapeutic target.

HS from ScienCell Research Laboratories are isolated from human synovium. HS are cryopreserved at passage one cultures ａnd delivered frozen. Each vial contains >5 x 10⁵ cells in 1 ml volume. HS are characterized by their fibroblast-like morphology, growth pattern ａnd immunocytochemistry of CD 90 ａnd fibronectin. HS are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi. HS are guaranteed for 15 population doublings at the conditions provided by ScienCell Research Laboratories.

Reference
[1]. Barland, P., Novikoff, A.B., Hamerman, D. （1962） Electron microscopy of the human synovial membrane. J Cell Biol. 14:207-220.
[2]. Kiener , H. P. ａnd Brenner, M. B. （2005） Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion. Arthritis Res Ther. 7（2）: 49-54.