联系我们

联系人：邓冉

点击查看联系方式

供应分类

产品展示

人颅骨成骨细胞

点击次数：301

价格：￥电议

更新日期：2026/8/24 23:48:28

生产地：美洲

产品型号：

简单介绍：人颅骨成骨细胞
骨骼是一类动态的组织，被破骨细胞系统和造骨细胞系统的调节活动不断重塑。造骨细胞是骨骼形成细胞，最初是来源于多能性的间叶干细胞。它们分泌、合成细胞外基质和主要含有I型胶原的的类骨质。类骨质被造骨细胞钙化，在此过程中，细胞在钙化物质中嵌入陷窝中变成骨细胞。当骨骼发育成熟时，造骨细胞的数量和大小减少，但休眠细胞依然可以对伤害做出反应，在骨折愈合过程中产生新的骨骼。在生命的后期，造骨细胞的活动受到甲状旁腺素循环水平的直接影响。造骨细胞表达蛋白酶活性受体1和血管内皮细胞生长因子。研究表明，无论在体内或体外，白血病抑制因子都能与造骨细胞表面结合诱导骨骼形成。颅骨缝合处造骨细胞的补充、增殖

商家名片

邓*

联系我时，请说明是阿仪网看到的，谢谢!

电话: 02*******563
手机: 18******401
微信:
交换名片后展示联系方式 → →

详细内容

推荐培养基:（ObM, Cat. No. 4601）

产地：San Diego,US
品牌：ScienCell

储存：液氮

运输：干冰

用途：科研

Bone is a dynamic tissue, being continuously remodeled by the coordinated actions of osteoclasts ａnd osteoblast lineage. Osteoblasts, the bone-forming cells, are derived originally from pluripotent mesenchymal stem cells. They synthesize ａnd secrete an organic extracellular matrix, osteoid, which is composed primarily of type I collagen. Osteoid is calcified by osteoblasts ａnd during this process the cells become encased in lacunae within the calcified material ａnd become osteocytes. As the skeleton reaches maturity, the number ａnd size of osteoblasts decrease; but dormant cells remain capable of responding to injury ａnd producing new bone as in the healing of a fracture. In later life, the activity of osteoblasts is influenced directly by circulating levels of parathyroid hormone. Osteoblasts express protease-activated receptor-1 ａnd vescular endothelial cell growth factor [1]. Studies show that Leukemia inhibitory factor can bind to the osteoblast cell surface ａnd induce bone formation both in vitro and in vivo [2]. The balance between osteoblast recruitment, proliferation, differentiation ａnd apoptosis in sutures between cranial bones is essential for calvarial bone formation [3].

HCO from ScienCell Research Laboratories are isolated from human calvariae. HCO are cryopreserved at primary cultures ａnd delivered frozen. Each vial contains >5 x 10⁵ cells in 1 ml volume. HCO are characterized by the cytochemically detection of AP ａnd mineral deposition. HCO are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi. HCO are guaranteed to further expand for 15 population doublings in the conditions provided by ScienCell Research Laboratories.

Reference
[1] Steinbrech, D. S., Mehrara, B. J., Saadeh, P. B., Greenwald, J.A., Spector, J. A., Gittes, G. K. ａnd Longaker, M. T. （2000） VEGF expression in an osteoblast-like cell line is regulated by a hypoxia response mechanism. Am. J. Physiol. Cell Physiol. 278: C853-C860.
[2] Dazai, S., Akita, S., Hirano, A., Rashid, M. A., Naito, S., Akino, K., Fujii, T. （2000） Leukemia inhibitory factor enhances bone formation in calvarial bone defect. J. Craniofac. Surg. 11（6）:513-20.
[3] Marie, P. J., Debiais, F., Hay, E. （2004） Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 ａnd BMP-2 signaling. Histol. Histopathol.17（3）:877-85.

人颅骨成骨细胞