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人绒毛膜滋养层细胞

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价格：￥电议

更新日期：2026/8/24 23:48:28

生产地：美洲

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简单介绍：人绒毛膜滋养层细胞
<7120> 人绒毛膜滋养层细胞 (HVT)提取于人胚胎绒毛膜滋养层组织，原代冻存。
胚胎滋养层是早期胚泡的外层遮盖物，并做为母亲子宫内膜和发育中胚胎之间的营养通路。紧贴在子宫壁的滋养层是胚胎着床必不可少的步骤，随后形成胎盘。覆盖着胎盘绒毛的人绒毛膜滋养层细胞提供母亲循环中氧和营养物质交换的介面。它们合成和释放绒毛膜促性腺激素，胎盘催乳激素和血管生成素，表达CXCR4, CCR5和泌乳刺激素基因家族。在绒毛锚定位点，它们分化成侵袭型并表达CCR1。绒毛膜滋养层细胞的特性及近期发现的滋养层干细胞，使它们成为一个研究细胞分化和器官形成的理想的遗传学平台。

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相关标签：人绒毛膜滋养层细胞

详细内容

推荐培养基:（TM, Cat. No. 7121）

产地：San Diego,US

品牌：ScienCell

储存：液氮

运输：干冰

用途：科研

The trophoblast begins as the outer covering of the early blastocyst ａnd provides the route of nourishment between the maternal endometrium ａnd the developing embryo. The trophoblast adhesion to the uterine wall is the requisite first step of implantation and, subsequently, placentation. Human villous tryophoblasts （HVT） covering the villi of the placenta provide the surface for the exchange of oxygen ａnd nutrient with the maternal circulation. They synthesize ａnd release chorionic gonadotropin, placental lactogen ａnd angiogenin [1]; expression of CXCR4, CCR5 ａnd prolactin gene family [2, 3]. They acquire CCR1 as they differentiate to an invasive phenotype at the villous-anchoring sites [4]. The feature of HVT together with the recent establishment of trophoblast stem cells makes them an ideal genetic platform to study cell differentiation ａnd organogenesis.

HVT from ScienCell Research Laboratories are isolated from human placental villi. HVT are cryopreserved at passage primary culture ａnd delivered frozen. Each vial contains >1 x 10⁶ cells in 1 ml volume. HVT are characterized by immunofluorescent method with antibodies to alpha- ａnd beta- HCG. HVT are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi. HVT are guaranteed to further culture the condition provided by ScienCell Research Laboratories.

Reference
[1] Pavlov, N., Hatzi, E., Bassagliam Y., Frendo, J. L., Brion, D. E., Badet, J. （2003） Angiogenin distribution in human term placenta, ａnd expression by cultured trophoblastic cells. Angiogenesis. 6（4）:317-30.
[2] Maldonado-Estrada, J., Menu, E., Roques, P., Vaslin, B., Dautry-Varsat, A., Barre-Sinoussi, F., Chaouat, G. （2003） Predominant intracellular expression of CXCR4 ａnd CCR5 in purified primary trophoblast cells from first trimester ａnd term human placentae. Am J Reprod Immunol. 50（4）:291-301.
[3] Wiemers, D. O., Ain, R., Ohboshi, S., Soares, M. J. （2003） Migratory trophoblast cells express a newly identified member of the prolactin gene family. J Endocrinol. 179（3）:335-46.
[4] Sato, Y., Higuchi, T., Yoshioka, S., Tatsumi, K., Fujiwara, H., Fujii, S. （2003） Trophoblasts acquire a chemokine receptor, CCR1, as they differentiate towards invasive phenotype. Development. 130（22）:5519-32.