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人尿道上皮细胞

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价格：￥电议

更新日期：2026/8/24 23:48:28

生产地：欧洲

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简单介绍：人尿道上皮细胞
<4320> 人尿道上皮细胞(HUC)提取于人膀胱组织，原代冻存。
人尿道上皮细胞排列在膀胱表面，它是由高可塑性和具有多种功能特殊类型的细胞组成。它们是膀胱防御系统的第一层，做为与病原体的接触面，它们具有多种防御机制来阻止病原体粘着，保持泌尿器溶解物的不渗透性。膀胱上皮细胞表达雌激素α、β受体，上皮生长因子受体和纤维母细胞生长因子受体，在损伤和感染时，这些受体对膀胱上皮细胞起着重要作用。它们还能释放许多细胞因子、免疫系统介质，这些新被认知的具有免疫调节潜在能力的尿道上皮细胞保证了最近两项发展的进一步研究：1)在实验室中培养正常膀胱上皮细胞的能力，2)免疫调节信号系统如何通过

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详细内容

推荐培养基:（UCM, Cat. No. 4321）

产地：San Diego,US

品牌：ScienCell

储存：液氮

运输：干冰

用途：科研

The urothelial cells, the cells lining the surface of the urinary bladder, are comprised of a unique cell type with high plasticity ａnd a variety of cell functions. They are the first line of bladder defense ａnd serve as an interface between pathogens that is equipped with several defense mechanisms to prevent adherence of pathogens ａnd maintain impermeability to urinary solutes. The urothelial cells express both estrogen receptor-alpha ａnd beta [1], epidermal growth factor receptor [2] ａnd fibroblast growth factor receptor [3] ａnd these receptors play a major role on urothelial cell response to injury ａnd infection. They also release a number of cytokines ａnd other immune system mediators ａnd this newly recognized immunoregulatory potential of the urothelial cell warrants further investigation through the application of two recent developments: 1） the ability to culture normal urothelial cells in the laboratory ａnd 2） the understanding of how immunoregulatory communications are generated for the biological functions of urothelial cells through signal transduction pathways.

HUC from ScienCell Research Laboratories are isolated from human bladder. HUC are cryopreserved at passage one ａnd delivered frozen. Each vial contains >5 x 10⁵ cells in 1 ml volume. HUC are characterized by immunofluorescent method with antibodies to cytokeratin-18, -19 ａnd vimentin. HUC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi. HUC are guaranteed to further expand for 15 population doublings in the condition provided by ScienCell Research Laboratories.

Reference
[1] Bjorling, D. E. ａnd Wang, Z. （2001） Estrogen ａnd neuroinflammation. Urology 57:40-46.
[2] Daher, A., de Boer, W. I., El-Marjou, A., van der Kwast, T., Abbou, C. C., Thiery, J. P., Radvanyi, F., Chopin, D. K. （2003） Epidermal growth factor receptor regulates normal urothelial regeneration. Lab Invest 83:1333-41.
[3]. Bassuk, J. A., Cochrane, K., Mitchell, M. E. （2003） Induction of urothelial cell proliferation by fibroblast growth factor⁻⁷ in RAG1-deficient mice. Adv Exp Med Biol 539:623-33.