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CHIR-99021 trihydrochloride（2mg）
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价格：￥电议
更新日期：2026/8/7 17:42:20
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相关标签：,,CHIR-99021,trihydrochloride（2mg）
详细内容
| 概述 | |
|---|---|
| 描述 | CHIR-99021 trihydrochloride is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. |
| 性能 | |
|---|---|
| 纯度 | ＞98% |
| 分子量 | 574.72 |
| 化学式 | CjQuery223007664599577120135_1634779686288H??Cl?N? |
| 分子结构式 |  |
| 溶解性 | DMSO: ≥ 32 mg/mL |
| CAS号 | 1782235-14-6 |
| 参考文献 | |
|---|---|
| [1]. Ring DB et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. [2]. Weikel KA et al. Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016 Sep 16;36(5). [3]. Ai Z et al. CHIR99021 enhances Klf4 Expression through β-Catenin Signaling and miR⁻⁷a Regulation in J1 Mouse Embryonic Stem Cells. PLoS One. 2016 Mar 3;11(3) [4]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24. [5]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24. | |
,,CHIR-99021,trihydrochloride（2mg）
