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phospho-Src(Tyr418)磷酸化Src原癌基因抗体
点击次数：268发布时间：2012/12/7
价格：￥电议
更新日期：2025/6/5 17:21:45
生 产 地：其它
产品型号：BY-3426R
详细内容
本公司经销phospho-Src（Tyr418），磷酸化Src原癌基因抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-Src（Tyr418）磷酸化Src原癌基因抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！
货号：BY-3426R
英文名称：Anti-phospho-Src（Tyr418）
中文名称：磷酸化Src原癌基因抗体
其他名称：名ASV; Avian sarcoma virus; c SRC; Neuronal CSRC tyrosine specific protein kinase; Neuronal SRC; Oncogene SRC; p60 Src; p60Src; pp60c src; pp60csrc; Proto oncogene tyrosine protein kinase Src; Protooncogene SRC; protooncogene SRC Rous sarcoma; SRC Oncogene; SRC1; Tyrosine kinase pp60c src; Tyrosine protein kinase SRC1; v src sarcoma （Schmidt Ruppin A 2） viral oncogene homolog avian; vsrc avian sarcoma （Schmidt Ruppin A2） viral oncogene homolog.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 60kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, chk, shp
产品介绍：Src （also known as pp60src） is a non receptor Tyrosine Kinase involved in signal transduction in many biological systems ａnd implicated in the development of human tumors. There are two critical phosphorylation sites of tyrosine on Src, tyrosine 418 ａnd tyrosine 529 （referring to human Src sequence）. The tyrosine 418 is located in the catalytic domain ａnd is one of the autophosphorylation sites. Full catalytic activity of Src requires phosphorylation of tyrosine 418. The tyrosine 529 is located near the carboxyl terminus of Src ａnd acts as a negative regulator, in that Src is held in the inactive form through an intramolecular interaction between the SH2 domain ａnd the carboxyl terminus when tyrosine 529 is phosphorylated by Csk. This conformation blocks phosphorylation of tyrosine 418 at the catalytic domain, thereby preventing Src activation. When tyrosine 529 is dephosphorylated, tyrosine 418 can be maximally phosphorylated ａnd Src becomes active. Src is a proto oncogene that may play a role in the regulation of embryonic development ａnd cell growth. Mutations in this gene could be involved in the malignant progression of colon cancer. Immunogen: Synthetic peptide （Human） derived from the region of Src that contains tyrosine 529, based on the human sequence. The sequence is conserved in mouse （tyrosine 534）, chicken （tyrosine 527） ａnd frog （tyrosine 525）.Subunit : Interacts with DDEF1/ASAP1; via the SH3 domain. Interacts with CCPG1.Subcellular Location : Cell membrane. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton.Tissue Specificity : Expressed ubiquitously. Platelets, neurons ａnd osteoclasts express 5-fold to 200-fold higher levels than most other tissues.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain.
货号：BY-3426R
英文名称：Anti-phospho-Src（Tyr418）
中文名称：磷酸化Src原癌基因抗体
其他名称：名ASV; Avian sarcoma virus; c SRC; Neuronal CSRC tyrosine specific protein kinase; Neuronal SRC; Oncogene SRC; p60 Src; p60Src; pp60c src; pp60csrc; Proto oncogene tyrosine protein kinase Src; Protooncogene SRC; protooncogene SRC Rous sarcoma; SRC Oncogene; SRC1; Tyrosine kinase pp60c src; Tyrosine protein kinase SRC1; v src sarcoma （Schmidt Ruppin A 2） viral oncogene homolog avian; vsrc avian sarcoma （Schmidt Ruppin A2） viral oncogene homolog.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 60kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, chk, shp
产品介绍：Src （also known as pp60src） is a non receptor Tyrosine Kinase involved in signal transduction in many biological systems ａnd implicated in the development of human tumors. There are two critical phosphorylation sites of tyrosine on Src, tyrosine 418 ａnd tyrosine 529 （referring to human Src sequence）. The tyrosine 418 is located in the catalytic domain ａnd is one of the autophosphorylation sites. Full catalytic activity of Src requires phosphorylation of tyrosine 418. The tyrosine 529 is located near the carboxyl terminus of Src ａnd acts as a negative regulator, in that Src is held in the inactive form through an intramolecular interaction between the SH2 domain ａnd the carboxyl terminus when tyrosine 529 is phosphorylated by Csk. This conformation blocks phosphorylation of tyrosine 418 at the catalytic domain, thereby preventing Src activation. When tyrosine 529 is dephosphorylated, tyrosine 418 can be maximally phosphorylated ａnd Src becomes active. Src is a proto oncogene that may play a role in the regulation of embryonic development ａnd cell growth. Mutations in this gene could be involved in the malignant progression of colon cancer. Immunogen: Synthetic peptide （Human） derived from the region of Src that contains tyrosine 529, based on the human sequence. The sequence is conserved in mouse （tyrosine 534）, chicken （tyrosine 527） ａnd frog （tyrosine 525）.Subunit : Interacts with DDEF1/ASAP1; via the SH3 domain. Interacts with CCPG1.Subcellular Location : Cell membrane. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton.Tissue Specificity : Expressed ubiquitously. Platelets, neurons ａnd osteoclasts express 5-fold to 200-fold higher levels than most other tissues.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain.
