Anti-phospho-SIRT6(Ser338)磷酸化沉默调节相关蛋白6抗体

本公司经销phospho-SIRT6（Ser338），磷酸化沉默调节相关蛋白6抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-SIRT6（Ser338）磷酸化沉默调节相关蛋白6抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5634R
英文名称：Anti-phospho-SIRT6（Ser338）
中文名称：磷酸化沉默调节相关蛋白6抗体
其他名称：名SIRT6（phospho S338）; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent deacetylase sirtuin-6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2L6; SIRT 6; SIRT6; SIRT6_HUMAN; Sirtuin （silent mating type information regulation 2 homolog） 6 （S. cerevisiae）; Sirtuin 6; Sirtuin type 6; Sirtuin6.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 39kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：NAD-dependent protein deacetylase. Has deacetylase activity towards ＇Lys-9＇ ａnd ＇Lys-56＇ of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates ＇Lys-9＇ of histone H3 at NF-kappa-B target promoters ａnd may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase ａnd for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels ａnd normal glucose homeostasis. Modulates cellular senescence ａnd apoptosis. Regulates the production of TNF protein.Function : NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac ａnd H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters ａnd may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase ａnd for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels ａnd normal glucose homeostasis. Modulates cellular senescence ａnd apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity ａnd can bind NAD（+） in the absence of acetylated substrate.Subunit : Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8.Subcellular Location : Nucleus, nucleoplasm.Similarity : Belongs to the sirtuin family. Class IV subfamily.Contains 1 deacetylase sirtuin-type domain.SIRT6是一种酶，能够从组蛋白的一个特定位点上移走称之为乙酰基组的化学物质。组蛋白对调控基因表达非常重要，而从组蛋白中移除乙酰基组就会“关闭”某些基因表达。 SIRT6蛋白与NF-kappaB（NF-kB）一同，可以调节凋亡、炎症和新陈代谢相关基因的作用。当减少SIRT6时，NF-kappaB变得过度活跃，开启同衰老相关的基因。