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TIMP1 Human/ 重组人金属蛋白酶1组织抑制物

TIMP1 Human/ 重组人金属蛋白酶1组织抑制物

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更新日期:2026/8/24 23:18:11

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简单介绍:TIMP1 Human/ 重组人金属蛋白酶1组织抑制物

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TIMP1 Human/ 重组人金属蛋白酶1组织抑制物

产品编号:ENZ-442
产品规格:2μg/10μg/1mg
Synonyms Metalloproteinase inhibitor 1, Tissue inhibitor of metalloproteinases, TIMP-1, Erythroid-potentiating activity, EPA, Fibroblast collagenase inhibitor, Collagenase inhibitor, TIMP1, CLGI, TIMP, EPO, HCI, FLJ90373.
Introduction TIMP1 is a member of the TIMP family. TIMP1 is an inducible glycoprotein produced by various cell types. The TIMP1 glycoprotein is a natural inhibitor of the matrix metalloproteinases, which a group of peptidases involved in degradation of the extracellular matrix. TIMP1 binds in a reversible mode to MMPs, with regions in the N-terminal domain binding to the MMP substrate-binding site. On top of its inhibitory function against most of the known MMPs, TIMP1 is able to promote cell proliferation in a broad range of cell types, and may also have an anti-apoptotic role. Furthermore, TIMP1 has erthyroid-potentiating activity via translocation to the nucleus and also inhibits apoptosis in B-cells.
The TIMP1 gene is situated within intron 6 of the synapsin I gene and is transcribed in the opposite direction. TIMP1 activity is dependent on the existence of disulfide bonds.
TIMP1 transcription is extremely inducible in reaction to many cytokines and hormones.
Increased TIMP1 levels are connected with squamous cell laryngeal carcinoma. TIMP1 overexpression is linked to gastric cancer.
Description TIMP1 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 184 amino acids fragment (24-207) having a total molecular mass of 25.21kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The TIMP1 is purified by proprietary chromatographic techniques.
Source Escherichia Coli.
Physical Appearance Sterile Filtered clear solution.
Formulation TIMP1 protein is supplied in 25mM Sodium acetate pH4.8 and 50% glycerol.
Stability Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Please avoid freeze thaw cycles.
Purity Greater than 95.0% as determined by SDS-PAGE.
Usage Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
TIMP1,Human,重组人金属蛋白酶1组织抑制物

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