金属蛋白酶组织抑制因子-4抗体 田源一抗

金属蛋白酶组织抑制因子-4抗体Anti-TIMP-4Metalloproteinase inhibitor 4; TIMP 4; TIMP4; TIMP metallopeptidase inhibitor 4; Tissue in
360TIYO.COM-上海田源公司

性能参数：

中文名称：金属蛋白酶组织抑制因子-4抗体
英文名称：Anti-TIMP-4
别名：Metalloproteinase inhibitor 4; TIMP 4; TIMP4; TIMP metallopeptidase inhibitor 4; Tissue in
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：The tissue inhibitors of metalloproteinases （TIMPs） are naturally occurring proteins that specifically inhibit matrix metalloproteinases ａnd regulate extracellular matrix turnover ａnd tissue remodeling by forming tightbinding inhibitory complexes with the MMPs. Thus, TIMPs maintain the balance between matrix destruction ａnd formation. An imbalance between MMPs ａnd the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. The TIMP proteins share several structural features including six loops held in place by six disulfide bonds arranged in three knot-like structures. These proteins also contain twelve cysteine residues in conserved regions of the molecule that form six disulfide bonds, essential for the formation of native conformations, ａnd the N terminal region that is necessary for inhibitory activities. The N terminus of each TIMP contains a consensus sequence （VIRAK） ａnd each TIMP is translated with a 29 amino acid leader sequence that is cleaved off to produce the mature protein. The C terminal regions are divergent, which enhances the selectivity of inhibition ａnd binding efficiency. Although the TIMP proteins share high homology, they may either be secreted extracellularly in soluble form （TIMP1, TIMP2 ａnd TIMP4） or bind to extracellular matrix components （TIMP3）. The MMPs ａnd TIMPs can be divided into two groups with respect to gene expression: the majority exhibit inducible expression ａnd a small number are produced constitutively or are expressed at very low levels ａnd are not inducible. Among agents that induce MMP ａnd TIMP production are the inflammatory cytokines TNF alpha ａnd IL1 beta. A marked cell type specificity is a hallmark of both MMP ａnd TIMP gene expression （i.e. a limited number of cell types can be induced to make these proteins）. Tissue Inhibitor of Metalloproteinases 4 （TIMP4） was identified by molecular cloning. TIMP4 shows 37 % amino acid identity with TIMP1 ａnd 51 % homology with TIMP2 ａnd TIMP3. TIMP4 is secreted extracellularly, predominantly in heart ａnd brain tissue. It may function in a tissue specific fashion in extracellular matrix （ECM） homeostasis. TIMP4 has a strong inhibitory effect on the invasion of human breast cancer cells across reconstituted basement membranes suggesting that TIMP4 may have an important role in inhibiting primary tumor growth ａnd progression. The human TIMP4 gene has the chromosomal location of 3p25.合成与降解（Synthesis ａnd Degradation） TIMP-4是TIMP家族的新成员，TIMP-3与TIMP-4同样具有较强的促凋亡、抑制血管生成、抗肿瘤浸润作用。

金属蛋白酶组织抑制因子-4抗体的质量标准：

■其它名称：	Metalloproteinase inhibitor 4; TIMP 4; TIMP4; TIMP metallopeptidase inhibitor 4; Tissue in
■交叉反应：	hu, mo, rat, Rb, cow, hrs
■产品类型：	一抗
■应用领域:	/肿瘤/神经生物学/合成与降解
■蛋白分子：	predicted molecular weight: 25kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human TIMP-4
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
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金属蛋白酶组织抑制因子-4抗体Anti-TIMP-4的相关产品目录：







1mg/1ml 金属蛋白酶组织抑制因子-4抗体 Anti-TIMP-4 Metalloproteinase inhibitor 4; TIMP 4; TIMP4; TIMP metallopeptidase inhibitor 4; Tissue in的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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