酪氨酸激酶B抗体 田源一抗

酪氨酸激酶B抗体Anti-Trk B/NTRK2TrkB; Tyrosine Receptor Kinase B; Tyrosine kinase,Pyk2; BDNF tropomyosine receptor kinase
360TIYO.COM-上海田源公司

性能参数：

中文名称：酪氨酸激酶B抗体
英文名称：Anti-Trk B/NTRK2
别名：TrkB; Tyrosine Receptor Kinase B; Tyrosine kinase,Pyk2; BDNF tropomyosine receptor kinase
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－

产品详细描述

产品介绍：The Trk family of nerve growth factor receptors includes Trk A（also referfed to as Trk A gp140）,Trk B ａnd Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor, gp140, the expression of which is restricted in vivo to neurons of the sensory spinal ａnd cranial gangliaof neurocrest origin. Nerve growth factor （NGF） stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines ａnd in embryonic dorsal root ganglia. By comparison, BDNF ａnd to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue ａnd primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation ａnd may recruit downstream dffector molecules to the ligand-bound receptor complex.Subcellular Location : Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein （By similarity）. Note=Internalized to endosomes upon ligand-binding （By similarity）.Tissue Specificity : Isoform TrkB is expressed in the central ａnd peripheral nervous system. In the central nervous system （CNS）, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, ａnd spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, ａnd dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney ａnd heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 Ig-like C2-type （immunoglobulin-like） domains. Contains 2 LRR （leucine-rich） repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Contains 1 protein kinase domain.Subunit : Exists in a dynamic equilibrium between monomeric （low affinity） ａnd dimeric （high affinity） structures. Interacts （phosphorylated upon activation by BDNF） with SHC1; mediates SHC1 phosphorylation ａnd activation. Interacts （phosphorylated upon activation by BDNF） with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation ａnd activation. Interacts with SH2B1 ａnd SH2B2. Interacts with NGFR; may regulate the ligand specificity of the receptor. Interacts （phosphorylated upon ligand-binding） with SH2D1A; regulates NTRK2. Interacts with SQSTM1 ａnd KIDINS220 （By similarity）. Interacts （phosphorylated upon ligand-binding） with FRS2; activates the MAPK signaling pathway.神经生物学相关蛋白（Neurobiology）此抗体针对NGF、BDNF、NT-3、NT-4等的受体包括trkA、trkB、trkC及NGFR。BDNF、NT-3能诱导trkB的酪氨酸磷酸化。（神经生长因子受体的一种）

酪氨酸激酶B抗体的质量标准：

■其它名称：	TrkB; Tyrosine Receptor Kinase B; Tyrosine kinase,Pyk2; BDNF tropomyosine receptor kinase
■交叉反应：	hu, mo, rat
■产品类型：	一抗
■应用领域:	/细胞生物/免疫学/神经生物学/信号转导/细胞凋亡/激酶和磷酸酶/细胞膜受体
■蛋白分子：	predicted molecular weight: 90-92kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human Trk B N-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－

质量投诉流程
1、向我们的客户服务部反应投诉原因及订单信息。
2、向我们发送投诉相关的证明材料。
3、田源时间进行质量投诉调查及处理调查结果。
4、田源将联系客户并提供质量投诉处理结果。

友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
1、超过质量投诉期的进口产品投诉
2、非质量报告提及的指标投诉

酪氨酸激酶B抗体Anti-Trk B/NTRK2的相关产品目录：







1mg/1ml 酪氨酸激酶B抗体 Anti-Trk B/NTRK2 TrkB; Tyrosine Receptor Kinase B; Tyrosine kinase,Pyk2; BDNF tropomyosine receptor kinase 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

查询其它抗体目录请点击本公司化工仪器网链接：http://www.chem17.com/st233816/erlist_675408.html

上海田源专业销售酪氨酸激酶B抗体 Anti-Trk B/NTRK2，了解更多请点击查询！