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Rabbit Anti- VEGFR2
点击次数：550 发布时间：2012/8/22 9:19:08
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Rabbit Anti- VEGFR2
Catalog Number : RS-0565R
Quantity size : 0.2ml （dilute with pH 7.4 0.01 M PBS or antibody diluent ）
Background:
VEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration ａnd differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises ａnd is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 ａnd phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 ａnd 1059 in the activation loop is required for activation of VEGF receptor 2 ａnd its intrinsic tyrosine kinase activity. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi＇s sarcoma lesions.
Rabbit Anti- VEGFR2
Specificity :
– anti- VEGFR2 is a rabbit monoclonal antibody unconjugated
– specific for VEGFR2 of rat
– epitope mapping near the amino term inus of VEGFR2 of rat origin
– use for elisa, immunoprecipitation ａnd immunohistochemistry
– Protein G affinity chromatogr aphy purification, purity :>95%
– Isotype: IgG
– mol wt: 151kDa
Application :
– Western blotting 1:100-500
– Immunohistochemistry 1:100-500
– ELISA 1:500-1000
– Optimal working dilutions must be determined by the end user.
Storage:
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃.
Important Note:
This product as supplied is intended for research use only, not for use in therapeutic or diagnostic applications.
Rabbit Anti- VEGFR2
原创作者：上海广锐生物科技有限公司
