Recombinant Romiplostim Protein, N-Fc 重组蛋白，AntibodySystem Laboratories

名称：Recombinant Romiplostim Protein, N-Fc 重组蛋白(EHE26002)

介绍：罗米司亭Nplate (Romiplostim)是一种血小板生成素(TPO)受体激动剂，模仿人体的天然TPO，旨在提升免疫性血小板减少症(ITP)患者血小板计数。免疫性血小板减少症(ITP)是—种罕见的、严重的自身免疫性疾病，特征为血液中血小板计数低(血小板减少症)和血小板生成受损。

链接：https://www.antibodysystem.com/product/10466.html

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邮箱：biolab-reagents@atagenix.com

QQ：2663991332

货号：EHE26002

靶点：Romiplostim

形式：Lyophilized

纯度：>90% as determined by SDS-PAGE.

表达系统：Mammalian

蛋白质长度：IEGPTLRQWLAARA

应用：SDS-PAGE,WB,ELISA,Immunogen,Bioactivity testing in progress

别名：罗米司亭、Nplate、Romiplostim

储存：Use a manual defrost freezer ａnd avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

参考文献：

Romiplostim Treatment of Chemotherapy-Induced Thrombocyenia. PMID: 31545663

A Review of Romiplostim Mechanism of Action ａnd Clinical Applicability. PMID: 34079225

Romiplostim. PMID: 18974747

A multicenter study of romiplostim for chemotherapy-induced thrombocyenia in solid tumors ａnd hematologic malignancies. PMID: 32499239

Romiplostim in adults with newly diagnosed or persistent immune thrombocyenia. PMID: 33249935

Efficacy ａnd safety of romiplostim in refractory aplastic anaemia: a Phase II/III, multicentre, open-label study. PMID: 33152120

Adults with immune thrombocyenia who switched to avatrombopag following prior treatment with eltrombopag or romiplostim: A multicentre US study. PMID: 35179784

Romiplostim: a review of its use in immune thrombocyenia. PMID: 22316355

Romiplostim in children with newly diagnosed or persistent primary immune thrombocyenia. PMID: 34308495

Romiplostim for the management of pediatric immune thrombocyenia: drug development ａnd current practice. PMID: 31239245

Romiplostim: a novel thrombopoiesis-stimulating agent. PMID: 19386944

Efficacy ａnd quality of life of Romiplostim in adults ａnd children with immune thrombocyenia: A review. PMID: 36550870

Romiplostim use in pregnant women with immune thrombocyenia. PMID: 36156812

Romiplostim in chronic immune thrombocyenic purpura. PMID: 19843480

Romiplostim management of immune thrombocyenic purpura. PMID: 19401474

Romiplostim drug presence in pregnancy ａnd lactation. PMID: 36848631

Development of Romiplostim for Treatment of Primary Immune Thrombocyenia From a Pharmacokinetic ａnd Pharmacodynamic Perspective. PMID: 27056734

Romiplostim ａnd eltrombopag for immune thrombocyenia: methods for indirect comparison. PMID: 22980701

Romiplostim: a breakthrough treatment for the management of immune thrombocyenic purpura. PMID: 19200304

Thrombopoietin receptor agonists: ten years later. PMID: 31073079

Experts＇ review: the emerging roles of romiplostim in immune thrombocyenia (ITP). PMID: 34313512

Use of Romiplostim during pregnancy as a rescue therapy in primary immune thrombocyenia: Literature review ａnd case description. PMID: 31116059

Romiplostim for the treatment of chronic immune or idiopathic thrombocyenic purpura: a single technology appraisal. PMID: 19804691

Development of romiplostim: a novel engineered peptibody. PMID: 25578414

Romiplostim for SARS-CoV-2 Vaccine Induced Immune Thrombocyenia. PMID: 34757966

Romiplostim: a second-generation thrombopoietin agonist. PMID: 19436840

Romiplostim for the management of perioperative thrombocyenia. PMID: 29767837

Immune Thrombocyenia in a Kidney Transplant Recipient Treated with Romiplostim. PMID: 35033295

Romiplostim-induced myelofibrosis. PMID: 24175353

Clinical overview ａnd practical considerations for optimizing romiplostim therapy in patients with immune thrombocyenia. PMID: 33781612

Thrombopoietin Receptor Agonists: Eltrombopag ａnd Romiplostim for the Treatment of Chronic Immune Thrombocyenia Purpura. PMID: 30880797

Romiplostim for PARP inhibitor-induced thrombocyenia in solid tumor malignancies. PMID: 36050822

Safety of romiplostim administered immediately after cord-blood transplantation: a phase 1 trial. PMID: 37589942

The development of romiplostim for patients with immune thrombocyenia. PMID: 21434943

A Review on Romiplostim Mechanism of Action ａnd the Expressive Approach in E. coli. PMID: 38282441

Immunomodulation with romiplostim as a second-line strategy in primary immune thrombocyenia: The iROM study. PMID: 37735543

Romiplostim for temozolomide-induced thrombocyenia in glioblastoma: The PLATUM trial. PMID: 31586022

Romiplostim in aplastic anaemia - another tool in the armamentarium. PMID: 33152102

Eltrombopag versus romiplostim in treatment of children with persistent or chronic immune thrombocyenia: a systematic review incorporating an indirect-comparison meta-analysis. PMID: 29330464

Thrombopoietin Receptor Agonists (TPO-RAs): Drug Class Considerations for Pharmacists. PMID: 34160821

Immunomodulation in Primary Immune Thrombocyenia: A Possible Role of the Fc Fragment of Romiplostim? PMID: 31214173

Spotlight on romiplostim in the treatment of children with chronic immune thrombocyenia: design, development, ａnd potential place in therapy. PMID: 28408804

Safety of romiplostim ａnd eltrombopag for children with immune thrombocyenia: a pharmacovigilance study of the FDA adverse event reporting system database. PMID: 36803342

Romiplostim for Primary Immune Thrombocyenia in Routine Clinical Practice: Results from a Multicentre Observational Study in Germany. PMID: 34959233

An ｕpdate on romiplostim for treatment of acute radiation syndrome. PMID: 35274632

Romiplostim-related myelofibrosis in refractory primary immune thrombocyenia: A Case report. PMID: 31232923

Romiplostim (Nplate()) as an effective radiation countermeasure to improve survival ａnd platelet recovery in mice. PMID: 31021662

Comparability of biosimilar romiplostim with originator: Protein characterization, animal pharmacodynamics ａnd pharmacokinetics. PMID: 36871442

Development of romiplostim for the treatment of patients with chronic immune thrombocyenia: from bench to bedside. PMID: 20298251

Successful treatment of refractory secondary immune thrombocyenia (antiphospholipid antibody syndrome-associated) with the combination of rituximab ａnd romiplostim at the cost of severe bone pain: A case report ａnd review of literature. PMID: 32611269

Romiplostim as Adjunctive Treatment of Refractory Amegakaryocytic Immune Thrombocyenia in a Dog. PMID: 33115689

Romiplostim for thrombocyenia following allogeneic stem cell transplantation: A case series. PMID: 30030975

Romiplostim use for thrombocyenia following allogeneic hemaoietic stem cell transplantation: a case series from a single center in Qatar. PMID: 37961987

Assessment of romiplostim immunogenicity in pediatric patients in clinical trials ａnd in a global postmarketing registry. PMID: 34638135

Romiplostim treatment for children with immune thrombocyenia: Results of an integrated database of five clinical trials. PMID: 32902132

Romiplostim in the management of the thrombocyenic surgical patient. PMID: 26033367

Romiplostim for Immune Thrombocyenia in Neuroblastoma Patients Receiving Chemotherapy. PMID: 29683946

Efficacy of romiplostim in treatment of thrombocyenia in children with Wiskott-Aldrich syndrome. PMID: 33131064

Romiplostim for management of chemotherapy-induced thrombocyenia. PMID: 24414994

Romiplostim for therapy-related thrombocyenia in pediatric malignancies. PMID: 28150377

A Novel Use of Romiplostim for SARS-CoV-2-induced Thrombocyenia. PMID: 33003146

Generic romiplostim for children with persistent or chronic immune thrombocyenia: Experience from a tertiary care centre in North India. PMID: 35467751

Romiplostim is effective for eltrombopag-refractory aplastic anemia: results of a retrospective study. PMID: 32876852

Romiplostim dose-response in patients with myelodysplastic syndromes. PMID: 23171070

The burden of immune thrombocyenia in adults: evaluation of the thrombopoietin receptor agonist romiplostim. PMID: 22533524

Romiplostim promotes platelet recovery in a mouse model of multicycle chemotherapy-induced thrombocyenia. PMID: 25754671

Romiplostim in children with immune thrombocyenia: a phase 3, randomised, double-blind, placebo-controlled study. PMID: 27103127

Romiplostim as early treatment for refractory primary immune thrombocyenia. PMID: 24068656

Romiplostim in patients undergoing hemaoietic stem cell transplantation: results of a phase 1/2 multicenter trial. PMID: 31805185

Quality by Design in Downstream Process Development of Romiplostim. PMID: 36439274

Assessment of romiplostim immunogenicity in adult patients in clinical trials ａnd in a global postmarketing registry. PMID: 32311075

High-dose romiplostim accelerates hematologic recovery in patients with aplastic anemia refractory to eltrombopag. PMID: 32616921

[Pharmacological ａnd clinical profile of romiplostim (Romiplate() 250 g for s.c. injection)]. PMID: 21747207

Romiplostim as a Therapeutic Intervention for Tacrolimus-induced Immune Thrombocyenia in a Pediatric Cardiac Transplant Patient. PMID: 33181586

Romiplostim Treatment in Adults with Immune Thrombocyenia of Varying Duration ａnd Severity. PMID: 26066765

Fate Determination Role of Erythropoietin ａnd Romiplostim in the Lineage Commitment of Hemaoietic Progenitors. PMID: 35489782

Severe romiplostim-induced rebound thrombocyenia after splenectomy for refractory ITP. PMID: 25325908