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如何实现2030年战胜脑膜炎?探索这些抗体蛋白在全球健康路线图中的关键角色
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言
2024年4月26日,卫生组织和法国政府将共同主办一场会议,导人强调了战胜脑膜炎的必要性,这是致残的主要原因之一。此,尼日利亚成功推出了一款新型、安全、的疫苗,针对非洲细菌性脑膜炎的五种主要菌株。在此基础上,实施“到2030年战胜脑膜炎”全球路线图,需要提供催化投资以采取行动。该路线图旨在预防近300万例脑膜炎病例和至少90万例死亡,并节省数十亿美元的医疗费用。路线图详细说明了预防、诊断、治疗和护理的措施,并强调提供支持和护理给因脑膜炎而致残的人。法国承办会议,呼吁全球共同努力应对脑膜炎挑战。世卫组织将继续支持各国制定本国的国家脑膜炎计划,推动实施路线图倡议。

Fig. 1.世卫组织和法国召开战胜脑膜炎会议
关于脑膜炎
脑膜炎(meningitis)是脑脊膜炎的简称,指发生于脑脊膜的急性或慢性炎症。脑脊膜是包裹大脑和脊髓的保护薄膜,包裹脑的部分称为脑膜,包裹脊髓的部分称为脊膜。
脑膜炎是神经系统常见的急危重症之一,病因涉及细菌、病毒、真菌、结核、寄生虫等多种病原微生物,往往起病急,临床表现多样,病死率和致残率高。脑膜炎幸存者可遗留包括耳聋、失明、癫痫、智力低下、运动障碍等神经系统后遗症。

Fig. 2.2017年各国每10万人口因脑膜炎发病率
脑膜炎涉及的蛋白抗体可以多种多样,这取决于它的病原类型(细菌性、病毒性、真菌性等)和研究或治疗的具体焦点。以下是一些与脑膜炎相关的蛋白及其抗体的例子,这些蛋白在病原体识别、免疫反应或疾病机制中发挥作用:
C-Reactive Protein (CRP):急性期蛋白,常用于评估身体的炎症水平。CRP水平在细菌性脑膜炎中往往显著升高,而在病毒性脑膜炎中升高较少。佰乐博为您提供一系列CRP相关的重组蛋白、抗体等科研试剂,为您在相关域的研究提供更多选择!
Protein:
Product Name | Catalog No |
Recombinant Human CRP, N-His | YHB99901 |
Antibody:
Product Name | Catalog No |
Anti-Human CRP Monoclonal Antibody (1A324) | MHB99901 |
Anti-Human CRP Monoclonal Antibody (1A325) | MHB99902 |
Anti-Human CRP Nanobody (SAA2074) | RHB99902 |
Anti-Dog CRP Monoclonal Antibody (1A424) | MQB99901 |
Anti-Dog CRP Monoclonal Antibody (1A425) | MQB99902 |
Anti-Dog CRP Monoclonal Antibody (1A426) | MQB99903 |
Anti-Human CRP Nanobody (SAA1358) | RHB99901 |
Anti-CRP Polyclonal antibody | PHB99901 |
Procalcitonin (PCT):常用于区分细菌性和非细菌性脑膜炎的生物标志物。PCT在细菌性脑膜炎中通常有显著的升高。佰乐博为您提供一系列PCT相关的重组蛋白、抗体等科研试剂,为您在相关域的研究提供更多选择!
Protein:
Product Name | Catalog No |
Recombinant Human PCT/Procalcitonin Protein, N-His | YHB93201 |
Recombinant Human PCT/Procalcitonin Protein, C-His | EHB93201 |
Antibody:
Product Name | Catalog No |
Anti-Human PCT/Procalcitonin Monoclonal Antibody (1A334) | MHB93201 |
Anti-Human PCT/Procalcitonin Monoclonal Antibody (1A335) | MHB93202 |
Interleukin-6 (IL-6):一种促炎细胞因子,其在脑膜炎的病程中表达上升,尤其是在细菌性脑膜炎中。佰乐博为您提供一系列IL-6相关的重组蛋白、抗体等科研试剂,为您在相关域的研究提供更多选择!
Protein:
Product Name | Catalog No |
Recombinant Human IL6 Protein, C-Fc | EHC15803 |
Recombinant Human IL6 Protein, C-His | EHC15802 |
Recombinant Mouse IL6 Protein, C-Strep | YMC15802 |
Recombinant Mouse CD126/IL6R/IL-6RA Protein, C-Fc | EMC36901 |
Recombinant Dog IL6/Interleukin-6 Protein, C-His | EQC15801 |
Recombinant Human CD126/IL6R/IL-6RA, N-His | YHC36901 |
Recombinant Human CD126/IL6R/IL-6RA, C-His | EHC36901 |
Recombinant Human CD130/IL6ST, N-His | YHE25301 |
Antibody:
Product Name | Catalog No |
Anti-IL6 Monoclonal antibody (10G10) | MHC15801 |
Anti-Mouse IL6 Monoclonal Antibody (1A093) | MMC15805 |
InVivoMAb Anti-Human IL6 (Iv0022) | VHC15801 |
Anti-Human IL6 Nanobody (SAA0798) | RHC15801 |
Anti-Human CD126/IL6R/IL-6RA Antibody (SAA0048) | FHC36910 |
Anti-CD126/IL6R/IL-6RA Polyclonal antibody | PHC36901 |
Research Grade Anti-Human IL6 (CNTO 345) | DHC15813 |
Research Grade Anti-Human CD126/IL6R/IL-6RA (PM-1) | DHC36905 |
Toll-like receptors (TLRs):在病原体识别和先天免疫反应中起关键作用的一组受体。特定的TLRs(如TLR2和TLR4)在细菌性脑膜炎中的作用特别重要。佰乐博为您提供一系列TLRs相关的重组蛋白、抗体等科研试剂,为您在相关域的研究提供更多选择!
Protein:
Product Name | Catalog No |
Recombinant Human CD282/TLR2, N-His | YHA95501 |
Recombinant Human CD284/TLR4, N-His | YHA05301 |
Recombinant Zebrafish TLR4/tlr4al Protein, N-His-SUMO | YWK52901 |
Recombinant Human TLR7, N-His | YHJ68601 |
Recombinant Human CD288/TLR8, N-His | YHJ65601 |
Recombinant Human CD283/TLR3, N-His | YHA53401 |
Recombinant Mouse CD283/TLR3 Protein, N-His | YMA53401 |
Recombinant Human CD290/TLR10, N-His | YHJ51001 |
Antibody:
Product Name | Catalog No |
Anti-Human CD282/TLR2 Antibody (T2.5) | FHA95530 |
Anti-Human CD289/TLR9 Antibody (5G5) | RHJ65501 |
Anti-Human CD284/TLR4 Nanobody (SAA1263) | RHA05301 |
Anti-Zebrafish TLR4/tlr4al Polyclonal Antibody | PWK52901 |
Anti-Human TLR7 Antibody (SAA1718) | RHJ68601 |
Anti-Human CD288/TLR8 Polyclonal Antibody | PHJ65601 |
Research Grade Anti-Human CD283/TLR3 (CNTO5429) | DHA53402 |
Anti-Human CD285/TLR5 Polyclonal Antibody | PHA95402 |
Matrix metalloproteinases (MMPs):这是一组酶,它们在炎症中调节细胞外基质的重组。在脑膜炎中,特别是MMP-9的水平可能会升高,有助于炎症的发展。佰乐博为您提供一系列MMPs相关的重组蛋白、抗体等科研试剂,为您在相关域的研究提供更多选择!
Protein:
Product Name | Catalog No |
Recombinant Mouse MMP9 Protein, C-His | EMD06801 |
Recombinant Human MMP8 Protein, C-His | EHD55101 |
Recombinant Mouse MMP7 Protein, N-His | YMC39601 |
Recombinant Rat MMP9 Protein, C-His | ERD06801 |
Recombinant Human MMP12, N-His | YHE24701 |
Recombinant Human MMP3 Protein, N-His | YHC32402 |
Recombinant Human MMP2 Protein, C-His | EHC32301 |
Antibody:
Product Name | Catalog No |
Anti-MMP9 Antibody (L51/80) | RHD06801 |
Anti-Human MMP25 Polyclonal Antibody | PHJ62601 |
Anti-cleaved MMP-9 Antibody (L103/15) | RHD06803 |
Anti-MMP9 Antibody (L51/82) | RHD06802 |
Anti-Human MMP8 Polyclonal Antibody | PHD55101 |
Anti-Human MMP3 Antibody (SAA1516) | RHC32401 |
Anti-Human MMP16 Antibody (SAA1573) | RHE82301 |
Research Grade Anti-Human MMP14 (KD014) | DHE75502 |
Bacterial Antigens:针对特定病原体的抗体,如针对脑膜炎奈瑟菌(Neisseria meningitidis)、肺炎链球菌(Streptococcus pneumoniae)、和B群链球菌(Group B Streptococcus)的蛋白抗体。佰乐博为您提供一系列Bacterial Antigens相关的重组蛋白、抗体等科研试剂,为您在相关域的研究提供更多选择!
Protein:
Product Name | Catalog No |
Recombinant Neisseria meningitidis NHBA Protein, N-His | YXX13201 |
Recombinant Streptococcus pyogenes speB/Strepain Protein, N-His-SUMO & C-Strep | YXX09202 |
Recombinant Listeria monocytogenes IAP/p60 Protein, N-His | YXX04201 |
Recombinant Escherichia coli Mcr1 Protein, C-His | YXX11001 |
Recombinant Mycobacterium tuberculosis esxA/ESAT-6 Protein, N-GST | YXX06101 |
Recombinant Mycobacterium tuberculosis esxB/CFP10 Protein, C-His | YXX15001 |
Recombinant Treponema pallidum/TP TPP15 & tmpA & TPP47 Protein, C-His | YXX06801 |
Recombinant Treponema pallidum/TP TPF1/Antigen 4D Protein, C-His | YXX06301 |
Antibody:
Product Name | Catalog No |
Anti-Neisseria meningitidis FHBP Antibody (1A12) | RXX14901 |
Anti-Neisseria meningitidis group B LPS/Lipopolysaccharide Antibody (SAA1462) | RXX02140 |
Anti-Neisseria meningitidis NHBA/Dextranase Antibody (5H2) | RXX13203 |
InVivoMAb Anti-Streptococcus pneumoniae iga/IgA1 protease Antibody (mAb2) | VXX17701 |
Anti-Haemophilus influenzae ompP1 Antibody (SAA1426) | RXX10701 |
Anti-Treponema pallidum TPF1/Antigen 4D Polyclonal Antibody | PXX06301 |
Anti-Listeria monocytogenes serotype 1/2a InlB/Internalin B Nanobody (SAA0997) | RXX07702 |
InVivoMAb Anti-Escherichia coli FedF Antibody (F9) | VXX12101 |
AntibodySystem
自从所有成员国批准“到2030年战胜脑膜炎”全球路线图以来,已经取得了重大进展。法国ProteoGenix科学团队注于重组蛋白和抗体产品的开发和定制服务,旗下AntibodySystem开发出一系列针对脑膜炎相关抗体产品及相关抗体药物研究。

原创作者:武汉佰乐博生物技术有限公司


