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转录因子Tbx18抗体；TBX18
点击次数：52
价格：￥电议
更新日期：2026/8/25 1:14:10
生 产 地：中国大陆
产品型号：50ul；100ul
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相关标签：转录因子Tbx18抗体；TBX18；抗体
详细内容
基本信息
产品名称： 转录因子Tbx18抗体；TBX18
规格： 50ul；100ul
介绍： 别 名T box 18; T box protein 18; T box transcription factor TBX18; T-box protein 18; T-box transcription factor TBX18; TBX18; TBX18_HUMAN.
产品名称： 转录因子Tbx18抗体；TBX18
规格： 50ul；100ul
介绍： 别 名T box 18; T box protein 18; T box transcription factor TBX18; T-box protein 18; T-box transcription factor TBX18; TBX18; TBX18_HUMAN.
研究域细胞生物 免疫学 染色质和核信号 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量65kDa
细胞定位细胞核
性 状Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TBX18:201-300/607
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍T-box transcription factors are a group of phylogenetically conserved genes that contain a uniquely defining DNA-binding domain, the T-box domain. These genes are believed to be involved in the regulation of development processes, for example the development of limbs, ａnd it is known that haploinsufficiency of multiple T-box proteins results in severe human congenital malformation syndromes, involving craniofacial, cardiovascular, ａnd skeletal structures. TBX 18 has been reported to be involved in numerous development processes ａnd to act as an antiapoptotic factor.
Function:
Probable transcriptional regulator involved in developmental processes.
Subunit:
Homodimer. Can form a heterodimer with TBX15. Interacts with GATA4 AND NKX2-5. Interacts with PAX3 (By similarity). Interacts (via engrailed homology 1 repressor motif) with TLE3; this interaction represses TBX18 transcriptional activity (By similarity) (PubMed:26235987). Interacts with SIX1 (PubMed:26235987).
Subcellular Location:
Nucleus.
转录因子Tbx18抗体；TBX18DISEASE:
Congenital anomalies of kidney ａnd urinary tract 2 (CAKUT2). The disease is caused by mutations affecting the gene represented in this entry. A disorder encompassing a broad spectrum of renal ａnd urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves ａnd ureter abnormalities. Congenital anomalies of kidney ａnd urinary tract are the commonest cause of chronic kidney disease in children.
Similarity:
Contains 1 T-box DNA-binding domain.
SWISS:
O95935
Gene ID:
9096
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转录因子Tbx18抗体；TBX18；抗体
