Crocin | 西红花苷

MCE 站：Crocin

中文名：西红花苷

CAS：42553-65-1

品牌：MedChemExpress (MCE)

存储条件：4°C, protect from light

生物活性： Crocin (Crocin I) 是一种营养保健品，是从 Crocus sativus 的柱头中分离出来的主要成分，具有抗炎、抗癌、抗抑郁和抗惊厥等巨大药理特性
^[1] .

体外：Crocin (150, 200 μM, 24 h) 通过抑制 JAK 通路在结肠癌细胞中发挥抗肿瘤作用
[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Crocin (20 mg/kg, 口服, 连续 5 周) 在大鼠中对博来霉素 (HY-108345) 诱导的肺纤维化具有显著的抗氧化、抗炎和抗纤维化作用
[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Bleomycin-induced pulmonary fibrosis in rat
[2] Dosage: 20 mg/kg Administration: p.o. Result: Reduced the expression of TLR4 ａnd IL-10. Reduced the expression of TNF-α ａnd TGF-β1. Clinical Trial

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研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

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参考文献：
[1]. Zaghloul MS, et al. Crocin attenuates lung inflammation ａnd pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis. Life Sci. 2019 Aug 26:116794.

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